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PROPOSEDAMENDEDSouth DakotaMEDIUM IMPACT

Rescheduling Psilocybin as a Schedule IV Substance

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PROPOSED LEGISLATIONThis bill has been introduced but has NOT been signed into law. Legislative proposals may be amended, passed, or fail to advance. This is not current law.

This proposed bill would reschedule the pharmaceutical composition of crystalline polymorph psilocybin in drug products approved by the Food and Drug Administration from its current classification to a Schedule IV controlled substance. This change would affect manufacturers, distributors, prescribers, and users of this specific form of psilocybin. The exact effective date is not specified.

Published March 10, 2026
WHAT CHANGED
BEFORE

Psilocybin was previously classified under a different schedule of controlled substances, and this bill proposes to change its classification to Schedule IV.

AFTER

This proposed bill would reschedule the pharmaceutical composition of crystalline polymorph psilocybin in drug products approved by the Food and Drug Administration from its current classification to a Schedule IV controlled substance. This change would affect manufacturers, distributors, prescribers, and users of this specific form of psilocybin. The exact effective date is not specified.

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